抖阴APP导航

With the iron lung of another generation鈥檚 polio epidemic for inspiration, a 抖阴APP导航 biomedical engineering research team is working with collaborators across the province and around the world on a modern machine to help coronavirus victims breathe.

While warning that their modern version of the iron lung would be a last resort due to lack of time to go through proper regulatory approvals, a team co-led by Dr. Mark Ungrin, PhD (pictured above), says that a negative pressure ventilation (NPV) device could help save lives if the current global pandemic leaves patients with no other options.  

鈥淭his ventilator is intended for use as a last resort if we don鈥檛 manage to 鈥榝latten the curve鈥� enough, and there just isn鈥檛 enough equipment to go around,鈥� explains Ungrin, associate professor of comparative biology and experimental medicine in the Faculty of Veterinary Medicine and the university鈥檚 Biomedical Engineering research and training programs, and member of the Alberta Children鈥檚 Hospital Research Institute at the Cumming School of Medicine (CSM).  

鈥淚t will be a bare-bones system with a basic level of functionality 鈥� we鈥檙e building parachutes, not airplanes," he adds.

Alberta's primary universities working together

Ungrin, along with University of Alberta mechanical engineering professor, Dr. Michael Lipsett, PhD, is heading a large team spanning the University of Calgary, the University of Alberta and the private sector. 

Other key 抖阴APP导航 figures include:  

• Dr. Salvatore Federico, PhD, a professor in mechanical and manufacturing engineering in the Schulich School of Engineering, and a member of the  Centre for Bioengineering Research and Education, and the Human Performance Laboratory

• Dr. Renaud L茅guillette, PhD, a professor in the Veterinary Clinical and Diagnostic Sciences department in the Faculty of Veterinary Medicine and member of the Libin Cardiovascular Institute at Cumming School of Medicine

The team鈥檚 NPV research is just one of the biomedical engineering projects underway at Alberta鈥檚 post-secondaries, as researchers look to bolster the efforts of frontline medical providers in combating the global pandemic.  

Not your grandfather's iron lung

In the case of Ungrin鈥檚 modern-day iron lung, the intent is not to replicate the massive, immobile machines that lined hospital wards during polio outbreaks in the 1940s and 1950s, but rather offer a lighter plastic chamber that could be used in a standard hospital bed.  

The purpose would be the same, however, in reducing stress on the lungs of a patient struggling to breathe, and the old iron lung idea has some advantages over the now more commonplace positive pressure ventilation (PPV) technology, which increases pressure within the lung.  

鈥淣PV systems work by reducing pressure around the patient's body, instead of increasing pressure inside the lungs. As they do not need to interact directly with the air the patient breathes, they can be simpler and easier to manufacture,鈥� says Ungrin.  

鈥淣PV patients can also wear standard oxygen supply systems, including masks to prevent infection, as the NPV system does not obstruct the face.鈥�  

A reliable design easily replicated

Ungrin鈥檚 team is consulting with public health agencies and other organizations as they prototype their system, aiming for a basic, safe and reliable design that is easily manufactured in large numbers.  

鈥淚f we can put a safety net in place, that鈥檚 one less thing for our frontline health-care workers to worry about,鈥� he explains. 

抖阴APP导航鈥檚 multidisciplinary Engineering Solutions for Health: Biomedical Engineering research strategy drives innovations that are saving lives and revolutionizing health care for Canadians. With collaborative teams focused on human mobility, health monitoring, advanced biomedical imaging, precision biodiagnostics, regenerative medicine and novel medical technologies, our researchers are transforming quality of life and continuously improving the health system. 

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